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-synuclein, which can be a main element of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, that's an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) tension, counsel that dysfunction from the intracellular proteinase methods, for instance ubiquitin-proteasome technique or lysosomal process, which eliminates avoidable harmfu